Directions (Dosage & Administration)
- Adults (18-64 years): 1 tablet (10mg) taken orally, immediately before bedtime.
- Elderly/Patients with liver impairment: Lower dose (3.75–5mg) may be recommended due to slower metabolism.
- Duration: Short-term use only (2–4 weeks) to avoid dependence.
- Take on an empty stomach for faster absorption (avoid heavy meals before dosing).
Side Effects
Common:
- Bitter/metallic taste in mouth (very frequent)
- Dry mouth, drowsiness, dizziness
- Headache, nausea
- Daytime fatigue (“hangover effect”)
Less Common/Serious:
- Memory loss, confusion, hallucinations
- Mood changes (aggression, depression)
- Sleepwalking or complex behaviors (e.g., eating/driving while asleep)
- Allergic reactions (rash, swelling)
Precautions
- Contraindications: Severe liver disease, respiratory disorders (e.g., sleep apnea), myasthenia gravis.
- Avoid alcohol: Increases sedation and risk of respiratory depression.
- Dependence risk: High potential for tolerance and addiction with prolonged use.
- Pregnancy/Breastfeeding: Not recommended (may harm the fetus/infant).
- Elderly: Higher risk of falls, cognitive impairment.
Drug Interactions
- CNS depressants: Enhanced sedation with opioids (e.g., codeine), benzodiazepines, antihistamines, or antidepressants.
- Enzyme inhibitors: Ketoconazole, erythromycin (increase zopiclone levels).
- Enzyme inducers: Rifampicin, carbamazepine (reduce zopiclone’s effect).
- Other: Clozapine (risk of respiratory failure).
Overdose
- Symptoms: Severe drowsiness, confusion, coma, respiratory depression.
- Treatment: Immediate medical help. Flumazenil may be used as an antidote in emergencies.
Missed Dose
- Skip if it’s almost time for the next dose. Never double-dose (risk of overdose).
Storage
- Store below 30°C, in original packaging, away from moisture.
- Keep out of reach of children (accidental ingestion can be fatal).
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